Through the state program of reforming health care and the Law «On protection of citizens’ health» have been integrated (joint) with research of ecology of environment with the participation of ecologists, mineral-geochemists and health workers. Industrial Centers (Tashkent-Angren-Almalyk, Tashkent, Navoi-Bekabad-Zarafshan, etc.) in which the population is due to the intensification of technological processes and the increasing load-nano structured aerosol pollutants are at risk of associated diseases. Wastes from production, enters the atmosphere, soil, water and vegetation with their unmanageable accumulation (overload) the impact of per person, causing a concomitant diseases (dental, skin, etc.), as well as the flora and fauna. Modern civilization has immunosuppressive effects on the human body with a set of related diseases, including the growth of dental coverage to working-age population [4,12]. In this regard, an important scientific problems of practical significance is drawn hygienic monitoring of the environment industry research centers with structural and mineral aerosol nano component (so-called «spit some») mass of air [11,14] on the antigen-toxicants.
In the industrial centers the sources of dangerous pollutants for human health (antigen-toxicants) are formed geologically and geochemical (or biogeochemical) antropo genious, biologically and cosmogeneous and other agents and processes taking place in the context of surrounding environment.
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Geology – and geochemical sources of fine shaped, nano structured and other mass disintegration and weathering of natural magmatic, metamorphic and sedimentary rocks and ores, including urban structures, and their subsequent transport and accumulation in aerosol formation.
Geological – geochemical factors of pollution over a huge territory, but actually related aerosol (spit some) mass richly represented in mineral components of nano structured forms (Table 1 and 2) whose components by Si, Al, Fe, Ca, Cu, etc., are essential in the increase of concentrations which acquire significance for the organism antigen-toxicant. In typical aerosol components the presence of a set of TR (rare earth elements, with 15), 
radioactive (U, Th, etc.) are of more than 70 items by all of the definitions.
In a concentrate of an aerosol dust the maintenance of aerosol aluminum (are extremely high, from less 10-74 to 20 weight.). According to modern representations [5,6,11] aluminum shows concentration at any maintenances in nano structure to the finding form, and so, nano parts, nano assembly and nano structured aluminum allocation require the special approach – sanitary-and-hygienic regulations. To itself of the similar approach of researches the form of stay of silicon which being in nano mineral dynamic values causes nano structures get the importance of harmful to an organism pollutes (an anti genetic – toxicants) environment.
By geographical factors forming aerosol pollutants by products of marine origin fumes aerosols iodine, bromine, chlorine, and possibly others. In the atmosphere of urban and suburban features of the industrial centers of growth aerosol sulfur, fluorine, phosphorus, chlorine and other pollutants are considered in relation to industrial activities (hydrogenous, sulfur dioxide, hydrogen sulfide, methane, etc.). Aerosol components of technogenic origin is extremely dangerous to the human body, which weakens its natural protective mechanisms that favor the development of numerous diseases, including dental (caries and its complications non caries defeat hard tissue of teeth, periodontal diseases and diseases of the mucous membrane of the mouth). Modern methods of prevention and treatment of dental diseases in industrial centers, with an unfavorable ecological situation is not always conducive to their full recovery. Prolonged treatment of diseases of periodontal and mucous membrane of the mouth often lead to the development of various complications (growth of resistant forms, and allergic reactions associated with the disease and others).
Atrophy genious (industrial) sources of aerosol pollution of the atmosphere are characteristic of areas of major industrial centers (Chirchik chemical factory, Ohangaron cement factory, Bekabad Metallurgical Plant, Almalyk hard-rock-metal Mill etc.), which makes a certain contribution to the aerosol trouble. Working vehicles worsen the environmental situation. Atrophy genious pollutants on the factors [7] when the formation is expanded: work on vehicles (up to 40% of the total number of Pollutant aerosol character) on the work of industrial enterprises, quarrying excavation of rocks and ores (40%) to eliminate waste production, and other debris, agricultural production (20%). Abnormal (man) aerosol pollutants provoke development of serious disease organism (allergic, endocrine, cardiovascular, urological, skin, dental etc.).
Cosmogenic sources of atmospheric aerosol components are involved in the dissemination of Fe, Mn, Ti, Si, N, C, Be, Li, B, and other chemical compounds. Cosmogenic radiation is accompanied by the formation of radioactive isotopes of carbon (12S14), hydrogen (1N3), beryllium (1Be7) and other radioactive isotope of carbon (12S14), with a half-T \u003d 5568 years, occurs due to the impact of neutron (n) for isotopes of nitrogen (N14): N14 + n → 12S14 + H1. Isotope of helium (He3) represents the product of the reaction of the dissolution of tritium (H3). Cosmogenic origin is and the radioactive isotope (1Be7), forming by splitting atoms of nitrogen and oxygen: 1Be7 [N14 + n → Be7 + ..] and 1Be10 with a half-T \u003d 53 days, respectively, and T \u003d 2.7 ∙ 106 years. Radioactive isotopes of carbon, beryllium, hydrogen and other chemical elements in rainwater enters the general circulation, are often adsorbed on the clay materials, structural components of soil organic substrate, etc. Bio elemental functional and organic violations of the organism are because of antigen – aerosol pollutants of industrial centers. The human body is characterized by the participation of virtually all chemical elements [9]. Sets of chemical elements in the matrix of the human body at an average weight (Table 3) are divided into macro and micro elements.